Why Antidepressants Don’t Work for Everyone: The Hidden Role of Trauma in Anxiety and Depression
Why Antidepressants Don’t Work for Everyone: The Hidden Role of Trauma in Anxiety and Depression
Are you or those you work with struggling with chronic fatigue, brain fog, anxiety, or emotional numbness, even though labs look “normal”? In this episode, Dr. Aimie explains how unresolved trauma stored in the nervous system can lead to a wide range of chronic physical and emotional symptoms that are often diagnosed as depression, anxiety, or autoimmune disorders.
Dr. Aimie breaks down the five-step trauma response that every body follows during threat, revealing why traditional treatments—like antidepressants or symptom-based approaches—often fail to create lasting healing. You’ll discover how trauma is not just psychological—it’s one’s physiological, deeply embedded in how the nervous system responds, stores, and gets stuck in survival patterns.
In this episode, you’ll hear the compelling story of Michelle, a teacher who “no longer felt like herself.” Through her story, you’ll learn what the body-trauma loop is and how it silently drives the common symptoms of exhaustion, disconnection, and chronic illness.
In this episode, you’ll learn:
How stored trauma creates physical symptoms like chronic fatigue, fibromyalgia, and gut issues
Why emotional disconnection and brain fog are often signs of a nervous system stuck in a trauma response
What happens in the first moments of threat and how the body decides whether to fight, flee, or freeze
The key difference between stress and trauma at a biological level
Why antidepressants may not work for trauma-driven depression and anxiety
This episode provides essential understanding for both practitioners and individuals seeking to identify the underlying patterns behind things like persistent anxiety, depression, chronic fatigue, and other conditions that don’t respond to standard treatments. It will give you the framework for understanding the biological foundation of trauma responses.
Helpful Links Related To This Episode
Guides, Tools & Resources:
- Steps to Identify and Heal Trauma: A Roadmap for Healing Trauma – Find out what trauma is, how to recognize it, and get simple steps to help you heal in this 23-page guide. It’s great for anyone who wants to understand trauma better or support others on their healing journey.
- The Essential Sequence – free guide that shows you the difference between stress and trauma states of our nervous system. In just 3 steps, it walks you through what your body needs when it has stored trauma or is in a freeze response.
- Biology of Trauma book – how the body experiences and holds fear, pain and overwhelm, and how to heal – at the time of this recording, The Insider’s Circle Book Club is open and pre-orders are going live soon.
- Brain Inflammation Protocol – The complete protocol for if you have anxiety, depression, prior head injuries and want to address the brain inflammation that’s keeping you stuck.
KEY MOMENTS:
- [05:45] Why your labs might look “normal” even when you feel terrible
- [07:20] Three ways your body protects itself during trauma
- [09:40] The five-step trauma response everyone’s body follows
- [11:55] What happens in the first seconds of danger
- [13:10] Why adrenaline, not cortisol, is the real stress hormone
- [15:25] The exact turning point when stress becomes trauma
- [17:00] What happens when your body hits the gas and brakes at the same time
- [19:40] How energy conservation during trauma creates chronic fatigue
- [23:35] The biology of chronic trauma and its link to somatic symptoms
- [27:50] How brain inflammation and gut health impact trauma and mental health
- [30:15] Why fibromyalgia, IBS, anxiety, and depression often occur together
- [32:45] Why healing stored trauma is essential for long-term recovery
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Disclaimer:
By listening to this podcast, you agree not to use this podcast as medical advice to treat any medical condition in either yourself or others. Consult your own physician for any medical issues that you may be having. This entire disclaimer also applies to any guests or contributors to the podcast. Under no circumstances shall Trauma Healing Accelerated, any guests or contributors to The Biology of Trauma podcast, or any employees, associates, or affiliates of Trauma Healing Accelerated be responsible for damages arising from the use of the podcast.